Chinese Academy of Sciences builds new materials for nano-biosensors to promote the development of the detection industry
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Huang Youju, a researcher at the Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, intensively cultivates nanomaterials and builds new materials for nanometer biosensors, aiming to promote more detection products into the homes of ordinary people.
It can be imagined that in the future, if you are worried about the fruits and vegetables, use this kind of test strip to measure it, and if there are any pesticides or indicators, you can see at a glance; even some human health indicators can use biosensors to convert into visible and tangible results. Intuitive presentation.
The research of the project harvested "unexpected joy"
Huang also held a university degree in polymer material science and engineering, and later entered China University of Science and Technology to pursue a doctoral degree. He firmly believed that if materials can be combined with the biological field, they will have very broad prospects for development. After graduating from PhD, he went to Nanyang Technological University in Singapore for post-doctoral research. His main research interests are in the field of chemistry and biomedical engineering.
“I had never been involved in nanoparticle research before I was a postdoctoral fellow. Later, because the research needed related materials, I only learned to synthesize nanoparticle materials. I didn't expect to show this talent.†4 years of advanced studies in Singapore allowed him to gain The "unexpected joy."
In October 2013, Huang Youju also entered the work of the Ningbo Institute of Materials Technology and Engineering of the Chinese Academy of Sciences through the "Spring Bud Talent" program. In December of last year, due to his outstanding scientific performance, he was promoted to a project researcher.
On the key issues such as the core material of nanobiosensors, Huang also studied for five or six years.
Nanogold materials are the focus of his research. Nanogold material is the core material of nanosensors and is widely used in test strips and test paper boxes. Its size, shape and self-assembly behavior directly affect the performance of visualization.
The traditional nanogold synthesis mainly regulates the morphology and size by regulating the reaction kinetics and thermodynamics, but many experimental parameters will often affect a large number of high-quality preparation of nanogold. Huang Youyi broke through the traditional method and proposed two new growth modes of nanogold: intelligent synthesis and discontinuous growth mode.
He has developed over 20 monodisperse gold nanoparticles with different morphology, including spheres, squares, rods, flakes, stars, lines, and some complex multi-stage nanostructures. Compared with other existing products, this synthesis method ensures that the nanoparticles can maintain high homogeneity of the particles under large-scale preparation conditions.
“There are defects in the purity and quality of nanogold particles on the market,†Huang also said. “The purity and quality of our products developed by our team are very high, and at the same unit price, we can produce larger bodies. Quantity of products."
The application of biosensors is very broad. "The application space of these sensors is very broad, and they mainly focus on some visual kits and test strips." He said, "The pregnancy test strips are more common on the market, and the direction of future applications is. It can also be targeted at audiences such as men and children, and it can also be a big issue in the area of ​​food safety.â€
For example, in the field of food safety, universal households want to test whether or not fruits and vegetables contain toxins. It is not possible to purchase large-scale instruments. Only a few simple tools can be used to identify them. Therefore, reagents and test strips that can observe color changes by the naked eye become an ideal tool. ,method.
"In the current environment of advocating 'precise medical care', more biosensors are needed to detect various types of human indicators in order to achieve prevention." Huang Youju is full of confidence in the prospect of research.
It is understood that the nanogold sample synthesized by him and his team has been favored and praised by a number of universities, institutes and companies at home and abroad. Samples have been used for free trials at Stanford University, Nanyang Technological University of Singapore, National University of Singapore, and Korea Sungkyunkwan. More than 30 institutions such as universities and various biological companies.
At the same time, he cooperated with many companies to develop some patents. Zhejiang Xingbo Biotechnology Co., Ltd. cooperated with it to develop a commercially available male reproductive health in vitro detection product.
This year, Huang Youyi also cooperated with Ningbo Meicheng Bio-Technology Co., Ltd. to establish the "Joint Laboratory for Rapid Materials and Technology for Food Safety Testing" at the Institute of Materials Science and Technology of the Chinese Academy of Sciences, and introduced more than 20 fast-checking portable instruments to conduct research on food detection technology. And applications, contention orientation provide third-party testing services.
Huang Youju said that at present, they are studying the issue of quantitative detection, mainly for a test strip and kit that can produce color changes with the change of target concentration. "For example, if you take a piece of test paper that detects toxins to detect something, the test paper can show the toxin content directly through different colors, just like the pH test paper shows different colors depending on the acidity and alkalinity concentration," he said.
He said that in the era of high-speed Internet development, visual biosensors can be combined with mobile healthcare, and the commercialization of biosensors can be realized through the construction of relevant biosensor chips, mobile phone APPs, and medical big data processing platforms.
(Original title: Using nano-biosensors, fruits and vegetables, whether or not there is a residue test paper to know)